Welcome to Onyx Scientific
Supporting our clients from medicinal chemistry to large scale commercial API production.
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Lead Optimisation
Using our expertise to focus on the delivery of key target compounds for our clients.
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Process Development
Taking your small scale chemical process to a much larger scale to support clinical programs.
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Chemical Synthesis
Providing mg to kg chemistry synthesis of new compounds, APIs, intermediates and many more.
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Scale-up & GMP synthesis
Utilise our MHRA and FDA licensed facilities for GMP synthesis, scale-up and production of APIs.
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Medicinal Chemistry Pre-clinical Phase I Phase II Phase III Commercial

About us

We’re a contract manufacturing pharma organisation (CMO) & chemistry contract research organisation (chemistry CRO) that provides pharmaceutical chemistry services to large and emerging pharma & biotech companies across the globe, helping accelerate candidates from discovery to production.

About us

Why Onyx?

With sites in the UK and India, we support clients from medicinal chemistry services through Phase I-III to large scale commercial API production. We are proud to be a preferred partner of many of the world’s top pharmaceutical firms and pride ourselves on being one of the leading chemistry companies in the UK.

This is why you should work with us...
Why Onyx?

Services

Services

Latest Event

We’ll be attending Pharma Integrates this November at the Riverbank Park Plaza, London. If you’d like to meet the team at the event on the 18th or 19th of November 2014 get in touch to pre-arrange a meeting.

Latest Event

Latest News & Views

  • Brian’s review of CPhI Worldwide 2014
    15 Oct 2014

    Paris is a beautiful city but after fighting through rush hour traffic for two hours from the centre of to Paris-Nord Villepinte, it didn’t much feel [...]

  • Adam’s review of ChemOutsourcing 2014…
    03 Oct 2014

    Back in a familiar setting once again for this thriving show, and one could sense the buzz of excitement whipped up immediately upon entering the lobby [...]

What our clients say

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      We were recommended to Onyx Scientific by an industry contact who had been very impressed with how they operated and delivered compounds. The team were able to take our project on at short notice and support us right away without any fuss. We have found the team to be responsive, competent and straightforward to deal with, which has been invaluable to our project.”

      —Tony Clarke, Director at Ricanto

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       Onyx Scientific has a niche in the market. As a contract manufacturing organisation that doesn’t have to bear the high costs of running a pilot plant, it can deliver high quality materials for IND-enabling toxicology studies and early phase development in a cost-effective manner. We would definitely recommend Onyx for anyone considering their options for scale-up and GMP synthesis.”            

      —Matthew Fyfe, Head of Chemistry at Topivert

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       Onyx Scientific is a truly outstanding partner in early API development and manufacture, combining high levels of technical ability, experience and commitment with a very collaborative approach and a focus on delivery. I have no hesitation in recommending them.”

      —Peter Spargo, Independent Consultant

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      We have found Onyx Scientific to be a cost-effective CMO for the API scale-up as well as the related analytical and solid-state development related to ESN364, Euroscreen’s clinical candidate currently in Phase I human clinical trials. In fact, we found Onyx to be cost competitive even when compared against certain Indian CMOs whilst offering the added advantage of proximity in terms of location (and time zone), ease of communication as well as their experience and know-how.  Additional attributes of Onyx that we find commendable are their flexibility and honesty – the latter is particularly stated in relation to their integrity in not trying to charge extras whenever possible.”

       

      —Hamid Hoveyda, Director of Chemistry at Euroscreen SA

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      AstraZeneca has worked with Onyx Scientific for many years for early-phase process development and supply of drug substance. This is clearly an area of expertise for Onyx and we continue to be impressed by their excellent technical capability, combined with their strong customer focus and collaborative approach. These qualities result in Onyx routinely meeting or exceeding our project requirements.”

      —Bill Moss, Process Chemistry Director at AstraZeneca

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      As we have moved towards advancing our clinical trial schedule, we have been very pleased with the continued commitment, expertise and support that Onyx Scientific has provided. The team’s flexibility and attention to detail throughout the process, including the adherence to stringent cleaning validation procedures, has assisted us in keeping our project on-track.”

      —Michael Roe, Chemistry & CMC Technical Manager at KalVista Pharmaceuticals

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      We were delighted with the service provided by Onyx Scientific in conjunction with Reach Separations in carrying out full characterisation and identification. The joint effort allowed us to undertake impurity synthesis to get a positive identification of impurity followed by the purification of a sample by prep LC. The whole process we found to be quick, efficient and cost effective.”

      —Sam Hubbard, Analytical Laboratory Manager at Oxford Analytical Ltd

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      The important thing for us when working with Onyx Scientific was the project was delivered on time and within budget. The team at Onyx communicated well and we were pleased with the quality of the final product.”

      —Dave Hamre, Pharmaceutical Project Manager at Special Products

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      We have worked with Onyx Scientific for a number of years and have been very impressed by their excellent flexibility and responsiveness throughout. They have demonstrated strong technical capability in carrying out PR&D scale up and GMP manufacture on multiple Phase I projects. By utilising their solid state offering alongside the PR&D work, this ensured a very efficient program with respect to salt selection. Vitally for us, their team has supported our application process through fast turnaround on any requests.”

      —Harshad Patel, Project Leader at Pulmagen Therapeutics

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      Onyx Scientific have shown themselves to be technically very capable when it comes to carrying out analytical projects. They took the time to understand our specific requirements and have come up solutions to overcome any challenges. Communication with the team has been particularly excellent given our contacts are easily accessible and contactable at any time. Importantly for us, speed of delivery was exceptional.”

      —David Childs, Director CMC at Shield Therapeutics

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      We were very impressed with the speed at which the team at Onyx Scientific initially responded to our enquiry. We required our compound within six weeks and were delighted to take delivery of our material well within this very tight timescale. Onyx’s team were friendly and knowledgeable, its facilities, equipment and reports were first class and the project on the whole ran incredibly smoothly.”

      —Dr Gavin Donoghue, Pharmaceutical Chemist at Syntopix Group PLC

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      Onyx Scientific provided an excellent service, responding very quickly to our needs with the flexibility that the nature of our work requires. They have coped easily with the higher volume of work and the data we are getting is as good as we could ask for. Its team continues to go beyond the call of duty and will enable us to make great progress going forwards. An outstanding experience all around.”

      —Dan Gooding, CEO at Nuformix Ltd

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      Cyclacel has worked closely with Onyx for a number of years. They have provided synthetic chemistry and analytical expertise for our late stage research programs and early development projects such that we could rapidly progress lead candidates through pre-clinical testing and into first in man studies. I have always found Onyx to be very customer focussed, flexible and responsive.”

      —Dr Ben Skead, Head of CMC at Cyclacel

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      The team at Onyx Scientific definitely provide value for money. They are reliable, meet deadlines making them a safe pair of hands and more cost effective in the long run than potentially cheaper competitors.”

      —Dr Nigel Westwood, Drug Supply Manager at Cancer Research UK

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      Over the ten years we have worked with Onyx Scientific, they have continuously expanded their services and kept up to date with the demands of the industry. As such, Onyx now provide an end to end chemistry solution and continue to deliver an outstanding service.”

      —Dr Daryl Rees, Chief Executive at Salupont Consulting

Contact us

Contact Us
For more information and to find out how our extensive range of services and expertise can help you, get in touch with us today.
Molecular Profiles Onyx Scientific is now providing a wider suite of services through our partnership with Molecular Profiles. Complementing our own expertise in chemistry and manufacturing APIs, Molecular Profiles is assisting our clients with advanced characterisation, formulation development, analytical support and clinical manufacturing.
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