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Given that a high percentage of all drugs are formulated in solid dosage form, the need to understand, control and characterise the individual forms of a drug substance, particular the polymorphic
form, is vital. Each polymorph displays unique physicochemical properties that can affect bioavailability, manufacturability, stability and other performance characteristics of the drug.
Similarly, production of bulk chemicals can often be hampered by poor process behaviour of key intermediates. Appropriate polymorphic form selection with desirable properties (e.g. for filtration)
can be of huge benefit to process efficiency and/or purity.
As the pharmaceutical industry continues to face an increasingly challenging regulatory climate, solid-state issues, particularly polymorphism plays an important part in Intellectual Property (IP)
strategy throughout a drug's life-cycle.
The following links provide additional information to the various aspects of our solid state and polymorphism services but please don't hesitate to contact us to discuss your specific needs.
 Physicochemical Property
Determination
Polymorph Screening
Salt Screening and Selection
Crystallisation Process Development &
Optimisation
Rapid Chiral Resolution Screening
Integrated Manufacturing & Solid State
Services
The emphasis at Onyx is to understand the customer's specific requirements from the outset so work programs can be designed to deliver the results necessary for a particular drug substance.
Contact us to discuss your specific requirements.
Contact Us
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Solid State
Chemistry
