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Our lead optimisation service focuses on the delivery of key target compounds. Our expertise in route design and parallel synthesis of small focused library sets of typically 5 to 50 compounds ensures your leads are efficiently optimised. Moreover, our knowledge and interpretation of SAR and biological data, together with in-house custom synthesis capability, allows us quickly and cost effectively select, optimise and progress leads to the next stage of development.
Typical services include:
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- Route scouting/design followed by first known synthesis
- Custom synthesis of analogues of lead and second generation compounds
- Custom synthesis of focused library sets (5-50 compounds, 5-250mg, >95% purity)
- Rapid scale-up of high priority compounds
Onyx Scientific provides a value added service with an emphasis on compound quality, purity and pharmacological properties.
Click here for an example of a small focussed library of amino thiophene compounds.
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Lead optimisation
Custom
Synthesis
