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Lead Optimisation

Our bespoke service encompasses a customer driven approach to the synthesis of key target compounds. Our expertise lies with route design and parallel synthesis of small focused library sets of typically 5 to 50 compounds.

Furthermore, our knowledge and interpretation of SAR data, together with in-house synthetic experience, allow us to quickly and cost effectively select, optimise and progress leads to the next stage of development.


Typical services include:
  • Route scouting/design followed by first known synthesis
  • Analogues of lead and second generation compounds
  • Focused library sets (5-50 compounds, 5-250mg, >95% purity)
  • Rapid scale-up of high priority compounds

Onyx Scientific provides a value added service with an emphasis on compound quality, purity and pharmacological properties.

Click here for an example of a small focussed library of amino thiophene compounds.

Lead optimisation
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